Kirish: Jahon sog'liqni saqlash tashkiloti ma'lumotlariga ko'ra, har yili dunyo bo'ylab 2 milliondan ortiq ayollarda ko'krak bezi saratoni tashxisi qo'yiladi. Bu dunyodagi ayollar orasida eng keng tarqalgan saraton bo'lib, har yili 700 ga yaqin000 odamni o'ldiradi.
Kasallik tashxisi qo'yilgan odamlarning taxminan 40 foizi mastektomiyaga to'g'ri keladi, bu esa ta'sirlangan ko'krak to'qimasini qisman yoki to'liq olib tashlashni o'z ichiga oladi. Biroq, zamonaviy davolash usullari bilan omon qolish darajasi 90 foizdan oshadi, ya'ni ko'proq ayollar yo'qolgan to'qimalarni almashtirish uchun ko'krakni qayta tiklash muolajalarini izlamoqda.
△Bioprinted breast implants contain patient cells to improve transplant success, image via Healshape
French Healshape A seriyasida 6,8 million mablag‘ oladi
2022-yil 23-yanvarda Antarctic Bear frantsuz regenerativ tibbiyot startapi Healshape A seriyasida tirik bemor hujayralaridan foydalangan holda 3D bioprinted ko‘krak implantlarini ishlab chiqish uchun 6,8 million (taxminan 43 million yuan) mablag‘ to‘plaganini bilib oldi.
Pulsalys SAS texnologiya transferi akseleratori tomonidan qoʻllab-quvvatlangan kompaniya 2020-yil yanvar oyida ishga tushirilganidan beri Frantsiyadan 1 milliondan ortiq pro-bono fondlari va subsidiyalar oldi.
Healshape's mission is to provide specific 3D bioprinted breast prostheses for breast cancer patients undergoing mastectomy. These implants can be printed in virtually any shape and size and can help rebuild breasts and nipples without the risk of implant rejection.
Sophie Brac de la Perrière, CEO of Healshape, said: "Female patients will have their breasts restored within 6 to 9 months, with no trace of a bioprosthesis. This will help patients accept their own image and recreate their own body. Satisfied."
△Healshape scientists 3D bioprinted custom breast implants, photo from Healshape
Ilgari, ko'krak rekonstruktsiyasi operatsiyasida odatda sun'iy implantlar yoki boshqa odamlar va hayvonlarning yumshoq to'qimalari matritsalari ishlatilgan. Ushbu manbalardan olingan implantlar har doim davolanish jarayonini kechiktirishi mumkin bo'lgan immunitet reaktsiyasi xavfi ostidadir.
Healshape's tissue engineering approach addresses these issues by combining 3D bioprinting technology with live cell cultures taken from the patient's own body.
Bioprinted so'rilishi mumkin ko'krak implantlari
Healshape's bioprosthetic technology relies on an absorbable hydrogel that can be 3D bioprinted into any freeform shape. Once implanted in the human body, fat transfer from the patient's own body cells facilitates the colonization of the breast implant and allows it to develop into natural breast tissue, while all of this hydrogel is gradually absorbed and replaced.
Healshape's technology is the result of a bioprinting study in collaboration with a research group led by Christophe Marquette, a senior researcher at the Institute for Molecular and Supramolecular Research at the French National Centre for Scientific Research (ICBMS). Marquette also leads the 3d.FAB platform and founded the tissue engineering company LabSkin Creations. Healshape's bioink technology is currently patent protected.
Marquette added: "Originally, the technology was developed for printing skin substitutes. For the Healshape project, it was necessary to adapt the process to print volumes and ensure subsequent consolidation of the bioink to make it compatible for implantation in vivo" .
Healshape's 3D bioprinting technology is currently in the preclinical stage, with clinical trials expected to begin within the next two years.
Global 3D bosib chiqarish ko'krak protezini tadqiq qilish jarayoni
2016-yilda ko‘krak bezi saratonidan aziyat chekkan Chjan Syue (taxallusi) Sszin kasalxonasida davolangan. O'sha paytda o'simta hajmi 6 sm dan oshdi va neoadjuvant kimyoterapiyaga qaramay, faqat total mastektomiya amalga oshirildi. Mutaxassislar ko'krak rekonstruksiyasi operatsiyasini kompyuter yordamida{2}}biologik parchalanadigan material plombalarini 4D bosib chiqarish orqali amalga oshirishga qaror qilishdi.
Jarrohlikdan oldin Sijing kasalxonasining radiologiya bo'limi jamoasi tomonidan yupqa qatlamli ko'krak MRI tekshiruvi o'tkazildi. Jarrohlik guruhi MRI orqali o'simta va ko'krak tasvirlari ma'lumotlarini aniq to'pladi va kompyuterda 3D rekonstruksiya va simulyatsiya qilingan rezektsiyani amalga oshirdi. Shu asosda, plomba o'lchami simulyatsiya qilingan to'qima nuqsoniga mos ravishda aniq ishlab chiqilgan va nuqson joyi 3D formatida bir -birdan- chop etiladi.
△ 4D printed biodegradable material filler
Operatsiya kuni direktor Ling Rui va Xijing kasalxonasining ko'krak tomirlari jarrohligi kafedrasi dotsenti Chjan Juliang kompyuter simulyatsiyasi natijalariga ko'ra chap ko'krak bezi saratoni va aksillar limfa tugunlari diseksiyasini keng ko'lamda olib tashlashdi. Ko'krakni muvaffaqiyatli qayta tiklash uchun{0}}oldindan ishlab chiqilgan 4D{2}}biologik parchalanadigan material plomba. Bemor operatsiyadan so‘ng yaxshi tuzalib, uchinchi kuni kasalxonaga yuborildi. Operatsiyadan keyin bemor muntazam ravishda radioterapiya oldi. Bir necha marta qayta tekshiruvdan so'ng{3}}implantlar asta-sekin shakllandi va to'qimalarga yaxshi mos kela boshladi va otologik fibrovaskulyar to'qimalar o'sishni boshladi.
2018-yilda Plimut universitetining ikki talabasi Rozi Brav va Sem Jekman ko‘krak saratonidan omon qolganlarning hayotini o‘zgartiradigan 3D{2}}bosma pushti soxta ko‘krakni ishlab chiqdilar.
Brave was inspired by Jackman's mother, who had had surgery and had traditional breast implants installed, but was confused by the "sweaty" and "uncomfortable" breast implants.
Shunday qilib, Brave va Jekman ko'krak implantlari dizaynini butunlay qayta ko'rib chiqishga va foydalanuvchiga quvonch keltiradigan dizaynlarni ishlab chiqishga kirishdilar. Ular yaratgan 3D bosilgan modellar rang-barang, engil va nafas oladigan bo'lib, ko'krak bezi saratoni va mastektomiya travmasini boshdan kechirganlar uchun yaratilgan.
2019-yilda Yangi Zelandiyada{1}}minimiyReflection{2}}meditsina ishga tushirilishi mastektomiyadan so‘ng saraton bemorlari uchun moslashtirilgan ko‘krak implantlarini ishlab chiqish uchun 3D skanerlash va 3D bosma qoliplardan foydalangan.
Protez tashqi o‘lchamlarni aniqlash uchun 3D skanerlash texnologiyasidan foydalanadi va ichki yadro va tashqi tomonida ISO{1}}sertifikatlangan silikon material bilan ishlab chiqilgan.
△Customized breast prosthesis made with 3D printing mold, picture from myReflection
2021-yilda Janubiy Koreya{1}}biotexnologiya startapi Plcoskin 3D-bosma ko‘krak implantlarining yangi turini yaratishga qaratilgan xalqaro qo‘shma tadqiqot loyihasiga rahbarlik qilishini e’lon qildi. Yonsey universiteti va Niderlandiyada joylashgan tibbiy asboblarni qoplash boʻyicha{3}}LipoCoat kompaniyasi bilan birgalikda Plcoskin kelasi uch yil ichida taxminan 2 milliard von (1,7 million) mablagʻ oladi.
2021-yilda 3D printerlar ishlab chiqaruvchisi 3D Systems yaqinda CollPlant regenerativ tibbiyot kompaniyasi bilan ko‘krak rekonstruksiyasini davolash uchun 3D bioprinted yumshoq to‘qimalar tuzilmalarini ishlab chiqish bo‘yicha hamkorlik shartnomasini e’lon qildi. Yumshoq to'qimalar tuzilmalari ko'krakning pastki qismini qo'llab-quvvatlash va implantning umumiy qoplamini oshirish uchun ishlatiladi. Healshape singari, yakuniy maqsad saratondan omon qolganlar uchun ko'krak rekonstruktsiyasi operatsiyasining muvaffaqiyatini oshirishdir.
